Follow these easy steps to create your Irresistible Spicy Southern Chicken Spaghetti Casserole:

1. Preheat the Oven: Begin by preheating your oven to 350°F (175°C).
2. Prepare the Pasta: Cook the spaghetti according to package instructions until al dente. Drain and set aside.
3. Mix the Sauce: In a large bowl, combine the cream of chicken soup, sour cream, diced tomatoes with green chilies, Cajun seasoning, garlic powder, onion powder, black pepper, and salt. Mix well until thoroughly combined.
4. Add Chicken and Pasta: Stir in the cooked spaghetti and shredded chicken. Ensure everything is evenly coated with the sauce.
5. Transfer to Casserole Dish: Grease a 9×13-inch casserole dish with olive oil. Pour the pasta and chicken mixture into the prepared dish, spreading it out evenly.
6. Add Cheese: Sprinkle the shredded cheddar cheese over the top of the casserole.
7. Top with Tortilla Chips: Crumble the tortilla chips over the cheese layer for added crunch and flavor.
8. Bake: Place the casserole in the preheated oven and bake for 30-40 minutes, or until heated through and the cheese is bubbly and golden brown.
9. Cooling Time: Once baked, remove the casserole from the oven and let it cool for about 10-15 minutes before serving.

These steps guide you through making a delicious casserole that your family will be talking about long after the meal is over.